Correlation of Glycated Haemoglobin with Protein Carbonyl Content as Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus

Introduction: Diabetes is chronic disease which characterised by defect in insulin secretion and action leading to hyperglycaemia. Aim: To detect protein carbonyl as oxidative stress marker Type 2 Mellitus (T2DM). Materials Methods: The present cross-sectional study was conducted on 100 subjects (aged 40 70 years) out of 50 were T2DM normal individuals. Serum tested for Fasting Blood Sugar (FBS) Glycated Haemoglobin (HbA1c) Protein Carbonyl Content (PCC). PCC measured spectrophotometric DNPH (dinitrophenylhydrazone) method Reznick AZ Packer L. Results: content, blood sugar HbA1c observed positively correlated type diabetes mellitus the levels PCC, FBS raised compared controls. Conclusion: Increased may be associated with generation oxygen free radicals form carbonyls decreased antioxidants T2DM.